Comparison of MIBG and Diphosphonate scintigraphy in cardiac involvement of aTTR-FAP
نویسندگان
چکیده
Background In familial aTTR amyloid polyneuropathy (FAP) cardiac involvement is of major prognostic value. Two approaches using radionuclide imaging proved relevant in the assessment of aTTR-related cardiac amyloidosis: detection of amyloid deposits with disphosphonates (DPD) and of sympathetic denervation with MIBG. The study aimed to compare the respective value of both approaches in patients with aTTR-FAP with suspected cardiac involvement.
منابع مشابه
Disphosphonates cardiac uptake in familial amyloid neuropathy: Comparison between DPD and HMDP
Background Familial amyloid polyneuropathy (FAP) is a severe hereditary disease, due to production by the liver of a genetic variant transthyretin (TTR) resulting in tissue amyloid deposits. Cardiac involvement is of major prognostic value. Diphosphonate scintigraphy has been proposed as a diagnostic tool for TTR-related cardiac amyloidosis, but there is no consensus on the optimal radiopharmac...
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عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2015